Introduction: Platinum-based drug cisplatin is frequently used as a first-line treatment for a variety of cancers. Despite its extensive anticancer efficacy, its use is constrained due to developed drug resistance and cytotoxicity to non-targeted normal tissues. Nephrotoxicity, ototoxicity, hepatotoxicity, and neurotoxicity are the major side effects of this drug. Objective: The cytoprotective efficacy of Daidzein, Naringenin, and Icariin against Cisplatin-induced hepatootoxicity in female Swiss mice was examined in this work. Methods: All animals were divided into two sets i.e. pre-cisplatin (BA) and postcisplatin (AA) administration and treated with Daidzein, Naringenin, and Icariin., hepatotoxicity we assessed by body weight and biochemical parameters i.e., SGOT, SGPT, lipid peroxidation (MDA level). Results: During this study body weight of the experimental animal changed by 5% maximum observed in both sets. Biochemical tests of blood samples and liver tissue histopathology showed that pre-treated and post-treated with Naringenin were more effective against hepatotoxicity as compared to daidzein and icariin. These findings are also confirmed by histopathology. Conclusion: The study has proven that pre-treatment with flavonoids was found more effective against cisplatin-induced cytotoxicity as compared to post-treatment.