Currently, consumers prefer nutrient-rich foods for health benefits. In this context, Broccoli, a cruciferous plant, in particular, is consumed worldwide as sprouts, and vegetables. The high bioactive ingredients like vitamins, vital minerals, phenolic compounds, glucosinolates, and others—have made it popular. Broccoli's nutritional value and pharmacological benefits are driving up its appeal day by day. Due to its many biologically active metabolites, broccoli's phytochemical makeup has been widely studied recently. There is a well-known positive correlation between secondary metabolites and their health benefits. Scientists recommend it for obesity, type-2 diabetes, cardiovascular disease (CVD), cancer, and osteoporosis. Many in vitro and in vivo researches on Broccoli showed a variety of noteworthy biological qualities, like anti-obesity, antioxidant, anti-inflammatory, anticancer, antimicrobial, anti-inflammatory, and antidiabetic effects. All these bioactive characteristics of Broccoli make it more valuable in the treatment of man. This review addresses an updated summary of bioactive components, bioactivities, and pertinent mechanisms of action of broccoli derivatives. By evaluating broccoli's wide range of nutrients, this review paper sought to determine its potential health advantages. Furthermore, it will also aid consumer food choices and nutraceutical and functional food applications.