Extrusion-based 3D printing technology represents a promising and relatively recent method with the potential to revolutionize the fabrication of pharmaceutical products across various dosage forms. Its distinct advantages over traditional manufacturing methods include enhanced precision in drug dosing, a critical factor for drugs requiring meticulous customization, such as those with a narrow therapeutic index. In this study, we successfully employed a syringe extrusion 3D printing technique to produce orodispersible films (ODFs) and compare their characteristics with those fabricated through the solvent-casting method. Different film-forming polymers like Polyvinyl Alcohol, Methocel and HPMC, PEG 4000, PEG 6000 & glycerin, and propylene glycol functioned as plasticizers. feasibility trials of film in 3d printer and by conventional method were performed. Mouth dissolving film was prepared successfully by 3D printing by pressure-assisted micro syringe method using HPMC K15 M and HPMC K100 M as polymer, Sucralose as sweetener, Citric Acid as saliva stimulating agent, PEG 400 and Glycerine as plasticizer, IPA and Water as solvent. So it can be concluded that mouth-dissolving film in both conventional methods and 3D Printing Methods. Formula by 3D printer by using a pressure-assisted micro syringe is ready for further trials with drug loading.