Background: Chronic kidney disease (CKD) is a major global health burden affecting millions of people worldwide. Among CKD treatments, hemodialysis is a cornerstone treatment that provides lifelong kidney replacement for patients with end-stage renal disease (ESRD). However, the effect of hemodialysis on the quality of life (QoL) of patients with CKD is of great interest and concern to health professionals and researchers. Objective: This cross-sectional analytical study aimed to investigate multifaceted aspects of the quality of life experienced byhemodialysis patients with chronic diseases. Methodology: A cross-sectional analytical study was conducted among 100 patients undergoing hemodialysiswho were selectedusing a simple random sampling technique after eligibility screening. Chronic kidney disease clients undergoing regular hemodialysis and free from critically ill patients were included in the study. The data have been collected using a demographic profile, clinical characteristics profile, and kidney disease quality of life instrument KDQOL scale to assess the quality of life. Data analysis was done by calculating the frequency and percentages of demographic profiles and clinical characteristics and for association Chi-Squaretest was used. Results: The analysis showed that, regarding age distribution, a maximum of 53% of participants fall within the range of 38 to 47 years, and 61% are from the male gender category. In view of the clinical profiles hypertension was notably higher among dialysis patients as a comorbid illness. Furthermore of the dialysis patients were receiving dialysis twice a week. In the blood lab clinical profile report data, a maximum of 39 % of patients were having issues with low hemoglobin levels between 6 – 8.5 g/dl along with this it was also noticed that serum urea levels show a clear majority in the range of 20.5 - 24 mg/dl (82%), Finally, body mass index (BMI) reveals 58% of participants categorized as obese. From the perspective of Quality of Life. The mean calculated value of quality of life mean is 33.3, indicating the average quality of life score across the study participants. Additionally, the standard deviation is reported as 4.085, reflecting the degree of variability or dispersion in the quality-of-life scores among the dialysis patients. A significant association was observed between gender and quality of life and Notably, a significant association was likewise found between serum sodium levels and quality of life (chi-square value 4.273, p-value 0.039*). Conclusion: The study has provided valuable insights into the quality of life (QoL) of chronic kidney disease (CKD) patients undergoing hemodialysis. Through a comprehensive exploration of various dimensions such as physical functioning as well clinical profile, and emotional well-being.