Patients with chronic kidney disease and ESRD are known as one of the high-risk groups for sudden cardiac death. Therefore, this study was conducted in order to determine the clinical outcomes of cardiopulmonary resuscitation in ESRD and dialysis patients and the factors affecting it in an academic tertiary hospital in west of Iran. In this retrospective crosssectional study, ESRD patients hospitalized or referred to the emergency department of our center who underwent cardiopulmonary resuscitation from 2021 to 2022 were included. Demographic and clinical information was collected and recorded from patient data file. The collected data were analyzed using SPSS v25. Of 112 patients included 72 cases (64.3%) were men and 40 cases (35.7%) were women. The mean and standard deviation of the age of the subjects was 66.86 ± 18.08 years. The average and standard deviation of the age of people by gender were 66.99±18.79 and 66.63±16.93 in men and women, respectively. 42 resuscitation cases (36.5%) were successful. Demographic factors (gender, age, education level, place of residence, height, weight and BMI), as well as initial heart rhythm and underlying diseases (hypertension, hyperlipidemia, previous history of CVA, myocardial infarction, cancer, drug poisoning, duration of dialysis), the witnessed arrest and the ward where resuscitation was done, had no significant relationship with the clinical outcome. Only the duration of resuscitation had a significant relationship with outcome and the success rate of resuscitation was less in prolonged resuscitation. Dialysis patients are usually complicated and suffer from multiplecomorbidities. In this study, no underlying factor with a significant relationship with the clinical outcome of cardiorespiratory arrest cases was foundwhich can suggest renal failure as an independent factor of increased mortality. Due to the contradiction in the results of some studies, perhaps a meta-analysis study on contradictory cases is more appropriate.