Background : Hormone Replacement Therapy (HRT) is widely employed to treat the climacteric symptoms, including hot flushes, night sweats and osteoporosis. But, due to its link with high risks of different types of cancer including breast, ovarian, and endometrial cancer it has warranted high level of research as to whether or not it is safe and effective. Objectives : The purpose of this current study is to assess the effects of HRT on the incidence of breast, ovarian, and endometrial cancers: the risks and benefits of HRT. Study design: A retrospective comparative cohort study. Place and duration of study. Department of endocronolgy hmc Peshawar from jan 2020 to jan 2021