This study set out to extract and describe it using UV spectroscopy. In addition, a thorough analysis of Atorvastatin Calcium's solubility profile over a range of media was conducted to comprehend its dissolving characteristics. In order to accurately identify and evaluate the Hibiscus Rosa-Sinensis mucilage powder with a comprehensive analysis of the physical and chemical characteristics of orodispersible tablets made with this natural excipient, extensive in-vitro drug release investigations were carried out. These studies provided important new information on the kinetics of drug release and the general functionality of the tablets, indicating a high degree of potential for medical use. A detailed stability analysis was performed on the optimized formulation, which confirmed its resilience and maintained efficacy over time. These findings collectively underscore the promising application of Hibiscus Rosa-Sinensis mucilage in pharmaceutical formulations, particularly for enhancing the solubility and bioavailability of poorly soluble drugs like Atorvastatin Calcium. This research paves the way for future advancements in drug delivery systems and underscores the importance of natural excipients in pharmaceutical development.