The use of plant-derived compounds in medicine has a long history, especially essential oils for their recognized complex mixture of bioactive compounds. The purpose of this investigation was to determine the chemical composition of the essential oil extracted from TourneuxiavariifoliaCoss. (Asteraceae), a Saharan plant that has not previously been investigated for its phytochemical or biological properties.The essential oil was obtained by hydro-distillation and analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS), resulting in the identification of 52 components out of a total of 78, which accounted for 99.91% of the oil. The major compounds identified were phthalate (14.19%), methyl linolenate (14.02%), germacrene-D (7.71%), methyl octadecan-10,13-dienoate (6.59%), and delta-cadinene (5.02%). This study provides valuable information about the chemical composition of the essential oil of Tourneuxiavariifolia. The presence of several bioactive compounds in high quantities, such as phthalate and germacrene-D, suggests the potential of this species as a source of natural products for various applications.