Typhoid fever is a significant public health concern in both developed and under developed nations. It is initiated by Salmonella enterica, specifically serotype typhi, and a general infection primarily transmitted through contaminated food and water sources. This study aimed to gather epidemiological data on typhoid patients at THQ Hospital Renala Khurd, Okara, and analyze hematological parameters to understand the disease's impact. Data was collected from typhoid patients by questionnaire during interviews, and blood was obtained for hematological analysis. It was found that there was non-significant difference in typhoid prevalence across different age groups. However, significant differences were observed based on education status, with implications for disease transmission dynamics. Marital status did not significantly influence typhoid incidence, although there was a slight difference observed between married and unmarried individuals. Urban residence did not significantly affect typhoid prevalence. Smoking status was not significantly associated with typhoid. Only middle-class families were included in study, may limit generalizability to other socioeconomic groups. Diabetic patients had less prevalence of typhoid than non-diabetic individuals, shows non-significant differences. Significant differences were observed in typhoid incidence based on food consumption, with those eating from contaminated sources being more susceptible. Hematological analysis revealed variations in between case and controls, suggesting potential diagnostic value. To conclude, various risk factors influencing typhoid transmission, including education, smoking, and diabetes status. While urban residence did not significantly impact on typhoid prevalence. Some factors such as smoking and diabetes were less associated with typhoid.