ISSN : 2663-2187

Impact of Zinc Supplementation on Immune Function in Pediatric Patients with Recurrent Infections: A Randomized Controlled Study

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Maria Asghar, Zohdum Malik, Sidra Zulfiqar, Dr Beenish Zafar, Dr.Marium Shoukat, Dr. Amtul Huda, Dr.Farah Naz Tahir
ยป doi: 10.48047/AFJBS.6.15.2024.11790-11799

Abstract

The relationship between recurrent infections in children and deficiency of one or more micronutrients, within which zinc is most crucial in immune modulation, has been studied. A not yet evaluated thorough review is, though, on the effects of zinc supplementation supplementary to other treatment modalities in recurrent infections in children and patients with zinc deficiencies. 150 children of 1-10 years were randomly assigned to a 75 control and 75 study group receiving zinc therapy over 12 weeks. Immune markers in respect to the treatment groups were tracked and measured which included T cell function, peripheral blood neutrophils, and serum zinc levels in patients taken at baseline and following interventions. The results showed that there was a statistically significant difference in serum zinc levels p<0.001 among participant groups and the control group intervention receiving 3 months of treatment with other placebos. There was also a significant increase in T-cell proliferation p=0.002 and neutrophil burst T-oxidative activity p=0.004 in patients who received zinc therapy. Key, zinc recipients also had fewer infections throughout the study, especially in respiratory tract infections p=0.01. Focus disease with particular emphasis on the evidence for immune effects of zinc and repeated and chronic respiratory infection in children aged 12 months to 10 years. These findings reveal new mechanisms for the immunological action of zinc in young patients with recurrent obstructive pneumonia and suggest its efficacy as a part of complex therapy in the treatment of recurrent bacterial infection in children.

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