The Momordicacharantia plant, also known as bitter gourd or bitter melon, is a crucial herbal remedy with a wide range of medicinal properties. It contains various essential phytocompounds, which contribute to its anti-inflammatory, antioxidant, and neuroprotective effects. DiNP phthalate is a common plasticizer used in polyvinyl chloride products, exposure is linked to increased oxidative stress and deregulations of genes linked to neurodegenerative diseases like Alzheimer's. In the present study, in silico molecular docking analysis of phytocomponents present in M. charantia fruit was studied against Oxidative Stressed genes (ACHE, MAPK9, SP1) associated with neurodegenerative disease pathways like Alzheimer's Diseases (A.D.). We docked the receptors are ACHE, MAPK 9, SP1 with the phytocompounds ofMomordicacharantiafruit. The result revealed that out of these 19 phytocompounds, Ajmalacine, Alkaloid AQC2, Alkaloid DF, Steroid U, and quinine were ranked the highest, with binding scores ranging from −11.0 kcal/mol to −9.1 kcal/mol compared with the standard, Armepavine, with a binding score of −6.6 kcal/mol. From the results obtained, it can be concluded that Ajmalacine, Alkaloid AQC2, Alkaloid DF, Steroid U, and quinine act/treat against Oxidative Stressed genes (ACHE), which are associated with neurodegenerative diseases like Alzheimer's Disease (A.D.).