Since ancient times, people have used plants to treat illnesses. Urolithiasis has been a problem for people worldwide for thousands of years. Nature has given our country a huge range of plants that can be used as medicine. Medicinal plants have been used for hundreds of years because they are safe, effective, culturally acceptable, and don't have as many bad side effects as manufactured drugs. Crystals in the urinary stream separate from urine and form kidney stones. These stones are small, hard deposits of minerals and acid salts. Biochemical processes, such as kidney formation and aggregation, cause renal stones to form. Nucleation is the process by which free ions in a fluid join together to form small particles. Crystals that were grouped were defined as having three or more different crystals that were tightly connected. A study is being done to determine how well plant medicines treat calcium oxalate crystals. Nucleation and aggregation tests were used to look at the study in vitro. The current study aims to find out how well Boerehavia diffusa and Celosia argentea work as antiurolithiatics. Plant extracts good at nucleation and aggregation could be used to make herbal medicines that help fight kidney stones. This study aimed to determine how well an extract from the leaves of Celosia argentea stopped calcium oxalate (Caox) from crystallizing in a lab setting.