The newly synthesised N-fused derivatives (2a-e) and (3a-e) are synthesised in eco-friendly method with trim in time, yielding good product results. These eco-friendly indolizine derivatives are essential in pharmacological activities. Alzheimer’s disease, affects the elderly and is chronic condition with no cure, and treatment is provided only for temporary relief. The disease possesses in two different forms of molecular series that target the multi-factorial aspects of the disease cells. The framework of designed molecule inhibits oxidative damage, acetylcholinesterase (AChE), and aggregation of Aβ fibrils that are the main aspect of disease and also exhibits good radical scavenging capacity. Certainly, these synthesised molecules show potential effective for Alzheimer’s disease. In addition, the derivatives were also screened for antifungal activities.