Application of green chemistry methods for synthesizing these derivatives aligns well with current environmental concerns and the need for sustainable practices in chemical synthesis. It's great to see efforts directed towards minimizing waste and ensuring the safety and quality of products. The process of synthesizing six derivatives of substituted phenyl thiazolidine-4-ones seems thorough, especially with the utilization of spectral analysis techniques like Mass, IR and NMR spectroscopy, along with results from elemental analyses. These analyses provide essential insights into the structural characteristics and purity of the synthesized compounds. Moreover, employing molecular docking studies to evaluate the affinity of these derivatives towards target enzymes COX-1 as well as COX-2 is a commendable approach. Acknowledging the collaboration of these compounds through their biological targets through computational methods like Auto Dock Vina can offer valuable predictive insights into their potential efficacy as anti-inflammatory agents. Overall, this study appears to be situated a comprehensive exploration of the biochemical properties of thiazolidine -4 one’s derivatives, with a focus on their anti-inflammatory activity. It holds promise for contributing to the development of innovative medicinal substances that are less harmful and more effective.