Mandarin (Citrus reticulata) is a fruit consumed largely in Algeria, belonging to the Rutaceae family. The aim of this study was to screening secondary metabolites and investigate the effect of ethanolic extract prepared from the fruit on the plasma antioxidant capacity and oxidative stress markers in CCl4 induced-damage in liver of mice. Oral administration of mandarin extract at doses of 200 and 600 mg/kg for 7 days enhanced protein levels with values of 10.26±0.181 and 12.36±0.407 mg/ml, respectively when compared to CCl4 group (10.10±0.071 mg/ml). Mandarin ethanolic extract showed a significant increase in catalase enzyme activity at a dose of 600 mg/kg (147.9±22.69 U/g tissue compared to CCl4 group (49.33±13.93 U/g tissue). GSH level was increased in dose dependent in the liver with 8.17±0.32, 10.35±0.27 nmol/g tissue, respectively compared to CCl4 group (6.663±1.25nmol/g tissue). The results showed that mandarin extract at doses of 200 and 600 mg/kg was more effective in enhancing antioxidant status in liver by reducing MDA level with 38.47±6.709 and 15.42±1.495 nmol/g tissue) when compared with CCl4 group (120.2±4.85 nmol/g tissue). Also, C. reticulata extract showed good plasma antioxidant activity using DPPH and reducing power assays. These results indicate that mandarin consumption can be used as hepatoprotective effect.