This study investigates the preparation and evaluation of Luliconazole and Posaconazolenanoemulgel formulations, aimed at enhancing the topical delivery and efficacy of these antifungal agents. Luliconazole and Posaconazole were incorporated into nanoemulsions and subsequently converted into gels using Carbopol 934. The formulations were characterized through various preformulation studies, including Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM) to ensure compatibility and stability. Nanoemulgel formulations were evaluated for their appearance, pH, drug content, viscosity, spreadability, and in vitro drug release.FTIR analysis confirmed the presence of characteristic functional groups for both drugs, while DSC thermograms indicated their crystalline nature with distinct melting points. SEM images revealed the crystalline morphology of the drugs. The nanoemulgel formulations, F1 (Luliconazole) and F2 (Luliconazole), demonstrated clear and slightly cloudy appearances, respectively, with pH values ranging from 6.5 to 7.1, suitable for skin application. The drug content was high across all formulations, ranging from 95.8% to 98.5%. Viscosity and spreadability tests indicated moderate to high consistency and ease of application. In vitro drug release studies showed that Formulation F2 provided the highest cumulative drug release of 98.4% at 8 hours, outperforming others. Antifungal efficacy, evaluated through inhibition zones, indicated that the standard formulation was more effective than the tested nanoemulgels against various fungal strains. These results suggest that the optimized nanoemulgel formulations offer a promising approach for improved topical antifungal therapy.