Introduction: Nephrotic syndrome (NS) is a common renal disorder. The present study is being conducted to understand the etiological spectrum of prevailing infections and their sensitivity pattern in children with nephrotic syndrome and correlate risk factors for culture- positive and associated risk factors. Methods: This study was conducted from January 2020 to December 2020 in the Department of Paediatrics, at a Single Tertiary Care Centre, Belagavi. The baseline presenting complaint was noted, and vitals, anthropometry, and detailed examination of the system affected in correlation with the symptoms were made in detail. Results: A total of 72 nephrotic syndrome children were admitted during the study period of which 44 had infections (61%). The prevalence of Nephrotic syndrome in our study was observed to be 61%. It was observed that in our study 30.77% of Culture-positive infections were due to UTI, 23.88% were due to sepsis, and 19.23 % were due to acute GE. There was a positive correlation with a p-value of 0.007 between clinical diagnosis and culture-positive infection which was significant in our study. 79.5% of the children who had major infections were on immunomodulators like cyclosporine (34.09%), Levamisole (27.27%), MMF (6.82%) and Tacrolimus (11.36%).