The purpose of this study was to evaluate the relationship among numerous variables to enhance the understanding of the effects of materials and process parameters on drug product quality and to develop a validated method for manufacturing of RABEPRAZOLE SODIUM 20 MG INJ.). Rabeprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube that connects the throat and stomach) in adults and children 12 year of age and older.