Modern medicine has involved the search for novel medications made from plant extracts. One such substance with several uses in human welfare is Morin. A metal contaminant that affects people everywhere is arsenic. The effectiveness of Morin was examined here in relation to the neurotoxicity of arsenic in rats. On days 7, 14, 21, and 28 of the trial, rat’s cognitive abilities were assessed using the Morris Water Maze, the Depression Test, and the Novel Object Recognition Test. In addition to estimating the levels of Acetyl Choline (Ach), dopamine, epinephrine, and norepinephrine in brain tissues, a histology investigation of the brain using two distinct stains H&E and Cresyl violet was also carried out. The Morin therapy has improved skills such as spatial and retention memory, according to the Morris Water Maze test. The Novel Objects Recognition test also showed improvement. There were no signs of depression during the Morin therapy. According to the findings, Morin therapy significantly (P) improved the content of dopamine, epinephrine, Non epinephrine, and Ach. Significant improvements in the architecture of the brain have been seen in histological studies of the hippocampus and cerebral cortex with H&E and Cresyl violet stain. Thus it can conclude that Morin is significantly beneficial in reducing Arsenic toxicity in rats.