ISSN : 2663-2187

Retrospective study of Hodgkin's and non-Hodgkin's lymphoma in the University Hospital Centre of Batna (Eastern Algeria) : Epidemiological, clinical and biological aspects

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Zidani Abla*, Belhadi Kamilia
ยป doi: 10.48047/AFJBS.6.13.2024. 1883-1895

Abstract

Background : Lymphomas are defined as cancers of lymphoid tissue. Both Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL) are types of lymphoma. Numerous studies carried out over the past two decades indicate a trend towards an increase in the incidence of lymphomas (especially NHL) worldwide (Baris and Zahn, 2000 ; Bosly and Coiffier, 1997). The epidemiological, clinical and biological features of lymphoma are little studied in Algeria. Aim : To study the epidemiological, clinical and biological characteristics of lymphomas in the hematology department at the University Hospital Center (HUC) of Batna (Algeria). Methods : This is a descriptive retrospective study on the records of 24 patients aged over 14 years with lymphoma, treated in the same department. The analysis revealed an average age of 40 years, men are more frequently affected than women (15 men/9 women), the sex-ratio is 1.66. Results : Our results reveal that there are 2 types of lymphoma, HL (58%) followed by NHL (42%). 62% were males and 38% females (sex ratio M/F= 1.66). The median age 29.21 years for HL and 51.7 years for NHL. Adenopathies for HL and especially abdominal pain for NHL were the main reasons for consultation. A predominance of stage IV (43%) followed by stage III (21%) for HL and a predominance of stage IV with (40%) followed by stage III (10%) for NHL. Cervical and axillary adenopathies (25%) were the most abundant for HL but for NHL were abdominal adenopathies with 34%. Secondary hepatic localization was predominant for HL and NHL. A predominance of the scleronodular type with 50% for HL and large B-cell NHL was predominant with 60%. Serology of Hepatitis B, C and human immunodeficiency virus (HIV) was negative. Biologically, a predominance of hyperleukocytosis, polynuclear neutrophilic leukocytosis, lymphopenia and hypoalbuminemia were present in the majority of HL and NHL cases.

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