Background:Cirrhosis of Liver is an end result of a variety of liver diseases characterized by fibrosis and architectural distortion of the liver with formation of regenerative nodules and can have varied clinical manifestations and complications. Objective:To identify the risk factors of Cirrhosis of Liver among patients attended in Gastro enterology department in a tertiary care hospital. Methods:A total of 118 participants, 59 cases of Liver Cirrhosis and 59 controls were selected by convenience sampling technique. Data collected by using socio demographic performa and disease related questionnaire. Socio demographic data was presented in terms of frequency and percentage for both case and control groups which determined the significant variables. Logistic regression with odds ratio (OR) was used to identify the relationship between the presence or absence of Liver Cirrhosis with presence or absence of risk factors. Results:Among the selected risk factors, Alcoholism (OR- 15.700, P value- 2.54e-09), Smoking(OR- 4.38, P value- 0.001) and Hepatotoxic Medications(OR- 2.170, P value- 0.109) were statistically significant after Univariate Logistic Regression. After Multivariate Logistic Regression, Alcoholism was found to be a risk factor for Cirrhosis of Liver (OR - 20.7, P value< 0.001). Conclusion:There is a significant relationship between the risk factors and Cirrhosis of Liver.