Diabetes mellitus, is characterized by elevated levels glucose in the body. To achieve good metabolic control in diabetes, a combination of pharmacological treatment and changes in the way of life is essential. There are various hypoglycemic agents such as herbal and synthetic drugs available for the treatment of diabetes. Herbal compounds are easily available, effective, have no side effects. In this comprehensive review article the reported hypoglycemic plants of India are helpful to the health professionals and scientists for developing alternative medicines to treat various types of diabetes. Treatment reduces the blood glucose level and other diabetic complications. Primary focus should be on changes in lifestyle. The aim of this article is to provide an update on the current and future benefits and restrictions of various drugs, for the treatment of diabetes.