Hyperlipidemia, characterized by elevated cholesterol levels, triglycerides, and low-density lipoproteins (LDL), is a major contributor to atherosclerosis and subsequent cardiovascular events. The coexistence of diabetes and hyperlipidemia poses a significant challenge due to their synergistic effects on cardiovascular risk. Novel 3,5- disubstituted thiazolidinediones were synthesized by the reaction of thiazolidinediones with biphenylcarbox aldehyde by Knoevenagel condensation reactions and the obtained products upon treatment with alkyl /aryl halides gave the synthesized products. The synthesized compounds were characterized by IR, NMR, and Mass spectra. The synthesized compounds were evaluated for anti-hyper lipidemic in alloxan-induced hyperglycemic rats and the compounds IId &IIf exhibited good control over hyperlipidemia when compared with pioglitazone. These studies were further asserted by molecular docking studies at the PPARα.