ISSN : 2663-2187

The Effect of Intravenous Tranexamic Acid on Reducing Blood Loss during Myomectomy Operation; Randomized Controlled Study: Review Article

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Ashraf Mohamed Nasr Refaee, Ahmed Hassan Zaki ElMasrawy, Khaled Fathi ElSayed Helal, Mohamed ElSayed Mohamed Nasr
ยป doi: 10.48047/AFJBS.6.13.2024.7993-8007

Abstract

The most frequent benign tumor in females is uterine myoma, which is derived from the myometrium of the uterus. Multiple studies have reported occurrence rates varying between twenty percent and forty percent. The histological diagnosis indicates a significantly higher frequency compared to the clinical diagnosis. Myoma is present in about sixty per cent of females over the age of forty-five. A laparoscopic, abdominal, or robotic myomectomy is an invasive medical operation. The abdominal incision is the most common method for carrying out a myomectomy surgery, as it allows the uterus to be easily closed in layers. The small port hole of laparoscopic myomectomy necessitates the application of supplementary equipment, such as a morcellator. The outcomes of robotic myomectomy have not yet been demonstrated to be greater to those of the laparoscopic technique. Tranexamic acid is one of the agents that is utilized. Tranexamic acid was utilized to decrease the necessity for allogeneic blood transfusions, particularly in cardiac operations, liver transplantation, and certain orthopedic surgical procedures, however, the outcomes were inconsistent. Tranexamic acid (TXA) (Kapron) is a synthetic analog of the amino acid lysine. TXA functions as an antifibrinolytic by reversibly binding to 4 to 5 lysine receptor sites on plasminogen. This prevents fibrin degradation and maintains the matrix structure of fibrin by reducing the conversion of plasminogen to plasmin.

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