Objective: This study aims to analyse the effect of a combination of red betel leaf decoction and basil on changes in plaque status and salivary pH in patients with type 2 diabetes mellitus. Methods: This study used quasi experiment with pretest-posttest with control group design. The research location was in the working area of Bara-Baraya health centre, Makassar. Random sampling with the criteria set with a total sample of 48 respondents consisting of 16 in the intervention group and 16 each in the comparison intervention group I and II. Data analysis used was paired sample test, one way anova, tukey test and kruskal wallis. Results: The study showed a difference in plaque status and salivary pH before and after the intervention of gargling a combination of red betel leaf decoction and basil with a p value of 0.000. Conclusion: The combination of red betel leaf decoction and basil has an effect on changes in plaque status and salivary pH in patients with Type II Diabetes Mellitus at Bara-Baraya Health Centre.