BACKGROUND: Postoperative nausea and vomiting are frequent issues after surgery, such as laparoscopic cholecystectomy. Gabapentin and dexamethasone have been recognized as potential treatments to lower the occurrence of nausea and vomiting and affect serotonin levels, which are involved in regulating nausea. This study seeks to evaluate the effects of gabapentin and dexamethasone on nausea and vomiting incidence and serotonin levels in patients undergoing laparoscopic cholecystectomy.