Background: This work focuses on measuring PIIINP levels in various hepatic fibrosis stages, examining the extent to which it may influence the rate at which liver fibrosis progresses, and estimating its diagnostic performance as a direct and complementary fibrosis marker. Methods: This research involved 291 individuals with clinically and laboratory proven chronic hepatitis C. Liver-fibrosis was determined by FibroScan. Results: PIIINP level was directly proportional to liver fibrosis progression yielding a Spearman’s rank correlation coefficient of 0.51 (P <0.0001). The mean value of PIIINP concentration was estimated to be 39.45 and 49.67 (ng/mL) in patients with F2-F4 and F4 while it was 15.60 and 19.77 (ng/mL) in case of patients with F0-F1 and F0-F3, respectively. Findings showed patients with F2-F4 and F4 displayed 2.56-fold and 2.65-fold increase in PIIINP over those with F0-F1 and F0-F3, respectively. To amplify difference in PIIINP among patients with different fibrosis-stages, PIIINP/platelets ratio was devised. Our results showed that PIIINP/platelets ratio enabled correct identification of F2-F4 and F4 showing AUCs 0.86 and 0.85, and displaying 3.72 and 3.56-fold increase over those with F0-F1 and F0-F3, respectively. Conclusion: PIIINP/platelets ratio is valuable liver-fibrosis marker that could improve liver fibrosis-staging and monitor disease-progression.