Zebrafish (Danio rerio) is a commonly used model organism in various fields of research, including dental studies. Zebrafish possess several advantages as a model organism, such as their small size, rapid development, transparency of embryos, and genetic tractability. These characteristics make them particularly suitable for studying various aspects of dental research, including tooth development, regeneration, and oral disease modelling. Here are some ways in which zebrafish can be utilized in dental studies. Zebrafish continuously develop replacement teeth throughout their lifespan, which makes them an excellent model for studying tooth development and regeneration. Researchers can investigate the genetic and molecular mechanisms underlying tooth formation by manipulating specific genes and observing the resulting phenotypes. This can provide insights into the molecular pathways involved in human tooth development and regeneration.