Background: This research article explores the intricate relationship between oxidative stress vascular ageing and yoga. Oxidative stress, arising from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms, plays a pivotal role in the physiological ageing process of blood vessels. Here, we dissect the molecular mechanisms underlying oxidative stress-induced vascular dysfunction, highlighting the involvement of key pathways such as endothelial dysfunction, inflammation, and vascular smooth muscle cell senescence. Furthermore, we discuss potential therapeutic strategies aimed at mitigating oxidative stress to prevent or delay vascular ageing and its associated pathologies with a special emphasis on yoga. The cross-sectional study aimed to explore the relationship between oxidative stress and vascular ageing and to dissect the effect of yoga in modulating this relationship. Materials and Methods: 135 age-matched participants of both genders were investigated for their oxidative stress parameters after segregation based on their yoga practice. Results: We found a significant (p<0.05) difference in the body mass index (BMI), and blood pressure (BP) phenotypes along with oxidative stress parameters in the participants performing regular yoga practice. Conclusion: Our study found a beneficial effect of yoga on blood pressure and endothelial function which act by decreasing oxidative stress and delaying vascular ageing. Overall, this article underscores the importance of understanding the complex interplay between oxidative stress and vascular ageing for the development of novel interventions targeting age-related vascular diseases with special emphasis on yoga.