This study explored Palmyra palm sprout powder (PPSP) as an excipient in Pioglitazone hydrochloride (HCl) tablets, comparing it with Microcrystalline Cellulose (MCC). Evaluated tablet properties included hardness, friability, disintegration time, dissolution profiles, flowability, compressibility, and stability. PPSP's biochemical analysis revealed reducing sugars, pentose sugars, hexose sugars, non-reducing polysaccharides, alkaloids, and mucilage, but no proteins or flavonoids. PPSP improved flowability and compressibility, indicated by a lower angle of repose and favourable Carr’s Index and Hausner’s Ratio. Seven tablet formulations (PG 1 to PG 7) with varying PPSP to MCC ratios were prepared. PG 3, with a 2:1 PPSP to MCC ratio, exhibited optimal characteristics: hardness of 4 kg, friability of 0.72%, and a disintegration time of 2 minutes. Dissolution studies confirmed PG 3 provided the highest drug release rates across all time points. FTIR analysis indicated no interactions between Pioglitazone HCl and the excipients, confirming the compatibility of the formulations. This comprehensive evaluation demonstrated that PPSP is a viable and effective alternative excipient, potentially enhancing the performance, manufacturability, and therapeutic efficacy of Pioglitazone tablets, thus offering improved patient compliance.